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NEW for JANUARY 2008

Call for BLOOD Samples for Addison’s:
http://cgap.ucdavis.edu/Addison's.htm

Although we continue to collect DNA from buccal swab samples, newer research technologies require DNA extracted from blood samples. Thus, we are seeking blood samples from affected and unaffected dogs. Affected dogs with veterinary diagnosis can be submitted from dogs of any age. For unaffected dogs, we especially need samples from dogs over the age of 7 years that are free from the disease. Please consider donating adrenal tissue from Addisonian dogs if euthanasia becomes necessary.

There is no fee for participating in this study although the owner bears the cost of blood collection and shipping of the sample to the laboratory. Some veterinarians may collect and ship samples at no charge for research purposes – please check with your veterinarian.

In the event that your dog’s DNA from the blood sample is used directly in the development of a commercially available diagnostic test developed by this laboratory, the results of the test for that dog will be provided at no cost upon your written request following the availability of that commercial test.

The Addison's work is a collaborative study between UC Davis, Åke Hedhammar in Sweden and Kerstin Lindblad-Toh of the Broad Institute. We appreciate your continued interest in our study.

Download blood sample submission instructions here:
http://cgap.ucdavis.edu/blood%20form%20request.htm

To request a buccal (cheek) swab kit:
http://cgap.ucdavis.edu/swab%20kit%20request.htm

To Update Your Dog's Health Status:
http://cgap.ucdavis.edu/healthupdateform.htm

If you have previously submitted a dog to our study, we would appreciate regular health updates, including if the dog is still healthy.

New submissions, please click submission form at left:
http://cgap.ucdavis.edu/healthupdateform.htm

If your dog is unaffected with the disease, please submit a health update annually, even if the dog is still healthy.

Please Note:
This kit is for participation in a research study only - it is NOT a test to verify if your dog does or does not have the disease. All submissions are confidential and results for individual dogs will NOT be made available.

CGAP Canine Genetic Analysis Project FAQs:
http://cgap.ucdavis.edu/FAQs.htm

CGAP. Copyright © 2008 UC DAVIS. All rights reserved.

http://cgap.ucdavis.edu/Default.htm

 

GDCA (Great Dane Club of America)
Dr. Anita Oberbauer at the CGAP (Canine Genetic Analysis Project) is requesting that Dane owners please donate samples to help us defeat Addison's Disease in this breed! We need individual dogs with a known health status. This means if you have an older Dane never diagnosed with Addison's, then this dog can be very helpful to her current research. Also Danes that have been diagnosed with Addison's are desperately needed!

Buccal swabs can be used, but the newer (and better-SNP assay) analysis really requires a blood sample, so if you can offer this, it's preferred. See the below for links and more information. Note also if you have submitted a Dane's DNA to this study, do be sure to periodically update that dog's file. Contact Dr. Oberbauer directly with specific questions about the research. For more information on Addison's Disease in the Great Dane, email danehealth@gdca.org

UPDATE on the Canine Addison's Disease project at UC Davis under the guidance of Anita Oberbauer (CHF Grant #225). This study has submitted it's first progress report. The summary of the research to date is as follows. Specific objectives are aggressively being pursued and the accumulation of data in several breeds, including our own, continues, and is progressing satisfactorily. To date DNA data on nearly 200 Danes has been collected. All Danes are eligible to join the study, with an emphasis on obtaining family data on individuals with Addison's disease. Research has already indicated than an autosomal recessive mode of inheritance is most likely for Addison's disease, as well as confirmed its genetic basis. Although ideally a test for the gene, and so for carriers of the gene, would be developed, even now the study's results offer breeders some control over the disease, and there has been some help as well on the clinical side as to more effective diagnosis and treatment. All this translates into an improved state of affairs as to health and welfare for our Danes. This study has recently begun to explore some techniques that may also help isolate the specific gene(s) involved in the expression of canine Addison's disease. Publication is also pending. The start date for this grant is 10--01-04 with a two year initial grant awarded. Application for enrollment in the program is directly available from the parent website or from UC Davis as well. It's important to remind Great Dane owners that updates on the health status of dogs enrolled are requested and significant to the accuracy of the data obtained. The GDCA is seeking Great Danes to participate in this study. ALL GREAT DANES ARE WELCOME!!! Families where at least one member has been diagnosed by a veterinarian with Addison's disease for a potential research project into the genetics and heritability of the disease in this breed are especially prized, but samples from anyone wishing to participate are wanted!
http://gdca.org/health/addisons.htm

 

 

Recent Progress on the Genetics of Canine Epilepsy and Addison's Disease
Presentation by Dr. Anita Oberbauer at the "Tufts Canine and Feline Breeding and Genetics Conference" (September 30-October 1, 2005), summarizing the current findings at UCDavis on Epilepsy and Addison's Disease: "...We believe this approach will yield chromosomal regions significantly linked to the Addisonian phenotype. The linkage, followed by gene identification and genetic sequencing to identify the precise mutation will enable the development of a diagnostic DNA based test for breeders to integrate into their breeding program. We are hopeful that the diversity of breeds under study will result in a test that is of utility to all breeds."
http://www.vin.com/proceedings/Proceedings.plx?CID=TUFTSBG2005&PID=10627&Category=1484&O=Generic

 

 

Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.
http://mercury.bio.uaf.edu/~george_happ/2006b.pdf

  

  

 

Nova Scotia Duck Tolling Retriever Addison's Studies
Separate UCDavis study - the inheritability of Addison's Disease in NSDTR's. Angela M. Hughes DVM, Veterinary Genetics Resident, Veterinary Medical Teaching Hospital.School of Veterinary Medicine, University of California, Davis, is undertaking a study on Addison's disease in the Toller. This is Dr. Hughes' resident research project and she will be conducting it under the guidance of Drs. Bannasch (Genetics), Oberbauer (Genetics), Famula (Statistics), and Nelson (Internal Medicine). 

NSDTR-USA: To request kits for the UC Davis Addison's Study on Tollers. To obtain the DNA sample is simple and easy by swabbing the inside of your dog's cheek.             http://www.nsdtrc-usa.org/HealthResearch.htm  

http://www.tollerhealth.com/Addisons.html

 

 

 

Scientists Hope to Study Addison’s Disease in Great Danes
Purina Pro Club publication 1/04: Announcement by UCDavis that their Addison's study would be expanded to include Great Danes (Catherine's diagnosis story was mentioned in this article!) Used with permission from the Purina Pro Club Update newsletters, Nestle Purina PetCare.
http://www.gdca.org/health/Great%20Dane%20104.pdf 

 

 

 

 

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