Research Studies
Articles, papers, publications, presentations, research studies


Canine Genetic Analysis Project (CGAP) Addison's Project
"Addison’s Project Breeds under study for this project:
Great Dane, Leonberger, Portuguese Water Dog, West Highland White Terrier

Blood Submission Instructions & Questionnaire
Request for Buccal Swab Kit
Canine Health Status Update Forms
What is Addison’s Disease (Hypoadrenocorticism)?
A deficient secretion of both glucocorticoids and mineralcorticoids from the adrenal cortex. The cause is unknown, but in most cases, there appears to be an immune mediated destruction of the adrenal gland. Symptoms include inappetance, vomiting, lethargy and weakness. An ACTH stimulation test can be used for diagnosis. The test is an evaluation of the ability of the adrenal gland to secrete cortisol. Affected dogs show low cortisol concentrations, and no increase in cortisol following the ACTH test. Treatment includes fluid therapy, replacement of glucocorticoids and mineralcorticoids, and hormone therapy. The FAQs link will answer many of your questions regarding the study. We appreciate your support and interest in the study."
Follow the links for more information.

GDCA (Great Dane Club of America)
Scientists Hope to Study Addison’s Disease in Great Danes
GDCA Article PDF file on this site.

Recent Progress on the Genetics of Canine Epilepsy and Addison's Disease
Presentation by Dr. Anita Oberbauer at the "Tufts Canine and Feline Breeding and Genetics Conference" (September 30-October 1, 2005), summarizing the current findings at UCDavis on Epilepsy and Addison's Disease: "...We believe this approach will yield chromosomal regions significantly linked to the Addisonian phenotype. The linkage, followed by gene identification and genetic sequencing to identify the precise mutation will enable the development of a diagnostic DNA based test for breeders to integrate into their breeding program. We are hopeful that the diversity of breeds under study will result in a test that is of utility to all breeds."

Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.

Nova Scotia Duck Tolling Retriever Addison's Studies
Separate UCDavis study - the inheritability of Addison's Disease in NSDTR's. Angela M. Hughes DVM, Veterinary Genetics Resident, Veterinary Medical Teaching Hospital.School of Veterinary Medicine, University of California, Davis, is undertaking a study on Addison's disease in the Toller. This is Dr. Hughes' resident research project and she will be conducting it under the guidance of Drs. Bannasch (Genetics), Oberbauer (Genetics), Famula (Statistics), and Nelson (Internal Medicine). 
NSDTR-USA: To request kits for the UC Davis Addison's Study on Tollers. To obtain the DNA sample is simple and easy by swabbing the inside of your dog's cheek.

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