NEW for JANUARY 2008! A
Research Focus on the Statistics & Molecular Genetics of Diseases in Dogs -
Department of Animal Science, UC DAVIS: Call for Blood Samples for Addison’s and
Epilepsy Diseases! Although we continue to collect DNA from buccal swab samples,
newer research technologies require DNA extracted from blood samples. Thus, we
are seeking blood samples from affected and unaffected dogs. Affected dogs with
veterinary diagnosis can be submitted from dogs of any age. For unaffected dogs,
we especially need samples from dogs over the age of 7 years that are free from
the disease. Please consider donating adrenal tissue from Addisonian dogs if
euthanasia becomes necessary. There is no fee for participating in this study
although the owner bears the cost of blood collection and shipping of the sample
to the laboratory. Some veterinarians may collect and ship samples at no charge
for research purposes – please check with your veterinarian. In the event that
your dog’s DNA from the blood sample is used directly in the development of a
commercially available diagnostic test developed by this laboratory, the results
of the test for that dog will be provided at no cost upon your written request
following the availability of that commercial test. The Addison's work is a
collaborative study between UC Davis, Åke Hedhammar in Sweden and Kerstin
Lindblad-Toh of the Broad Institute. We appreciate your continued interest in
our study.
http://cgap.ucdavis.edu/Default.htm
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UCDavis study of Addison's
Disease in dogs
UCDavis is collecting DNA from several breeds, including
Bearded Collies, Great Danes, Leonbergers,
Portuguese Water Dogs, Standard Poodles and West Highland White Terriers for
a research study of Canine Addison's Disease! Current studies of Canine
Addison's Disease at UCDavis. **PLEASE NOTE: These
studies need DNA samples from ANY and ALL representatives of the breed:
Affected, UNaffected, Related, UNrelated to dogs that have been diagnosed with
Addison's Disease! Please send for your kits today! It's important to remind
owners that updates on the health status of dogs enrolled are requested and
significant to the accuracy of the data obtained!
http://cgap.ucdavis.edu/addison's.htm
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UCDavis Health Status
Update Form (for samples already submitted)
To update the health status of your dog,
who has already been submitted to the study, All submissions are
confidential.
http://cgap.ucdavis.edu/healthupdateform.htm
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Recent
Progress on the Genetics of Canine Epilepsy and Addison's Disease
Presentation by Dr. Anita Oberbauer at the "Tufts Canine and Feline Breeding
and Genetics Conference" (September 30-October 1, 2005), summarizing the
current findings at UCDavis on Epilepsy and
Addison's Disease: "...We believe this approach will yield chromosomal
regions significantly linked to the Addisonian
phenotype. The linkage, followed by gene identification and genetic
sequencing to identify the precise mutation will enable the development of a
diagnostic DNA based test for breeders to integrate into their breeding
program. We are hopeful that the diversity of breeds under study will result
in a test that is of utility to all breeds."
http://www.vin.com/proceedings/Proceedings.plx?CID=TUFTSBG2005&PID=10627&Category=1484&O=Generic
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Association of canine
hypothyroidism with a common major histocompatibility complex DLA class II
allele
Dogs exhibit a range of immune-mediated
conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an
association in Doberman Pinschers between canine hypothyroidism and a rare
DLA class II haplotype that contains the
DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs
in a range of breeds where a significant association with DLA-DQA1*00101 is
shown.
http://mercury.bio.uaf.edu/~george_happ/2006b.pdf
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GDCA (Great Dane Club of
America)
UPDATE on the Canine Addison's Disease
project at UC Davis under the guidance of Anita Oberbauer
(CHF Grant #225). This study has submitted it's
first progress report. The summary of the research to date is as follows.
Specific objectives are aggressively being pursued and the accumulation of
data in several breeds, including our own, continues, and is progressing
satisfactorily. To date DNA data on nearly 200 Danes has been collected. All
Danes are eligible to join the study, with an emphasis on obtaining family data
on individuals with Addison's disease. Research has already indicated than an
autosomal recessive mode of inheritance is most likely for Addison's disease,
as well as confirmed its genetic basis. Although ideally a test for the gene,
and so for carriers of the gene, would be developed, even now the study's
results offer breeders some control over the disease, and there has been some
help as well on the clinical side as to more effective diagnosis and
treatment. All this translates into an improved state of affairs as to health
and welfare for our Danes. This study has recently begun to explore some
techniques that may also help isolate the specific gene(s) involved in the
expression of canine Addison's disease. Publication is also pending. The
start date for this grant is 10--01-04 with a two year initial grant awarded.
Application for enrollment in the program is directly available from the
parent website or from UC Davis as well. It's important to remind Great Dane
owners that updates on the health status of dogs enrolled are requested and
significant to the accuracy of the data obtained. The GDCA is seeking Great
Danes to participate in this study. ALL GREAT DANES ARE WELCOME!!! Families
where at least one member has been diagnosed by a veterinarian with Addison's
disease for a potential research project into the genetics and heritability
of the disease in this breed are especially prized, but samples from anyone
wishing to participate are wanted!
http://gdca.org/health/addisons.htm
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Nova Scotia Duck Tolling
Retriever Addison's Studies
Separate UCDavis
study - the inheritability of Addison's Disease in NSDTR's.
Angela M. Hughes DVM, Veterinary Genetics Resident, Veterinary Medical
Teaching Hospital.School of Veterinary Medicine, University of California,
Davis, is
undertaking a study on Addison's disease in the Toller. This is Dr. Hughes'
resident research project and she will be conducting it under the guidance of
Drs. Bannasch (Genetics), Oberbauer
(Genetics), Famula (Statistics), and Nelson
(Internal Medicine).
http://www.tollerhealth.com/Addisons.html
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Nova Scotia Duck
Tolling Retriever: Toller Health-USA (form to request test kits for the
UCDavis study)
NSDTR-USA: To request kits for the UC
Davis Addison's Study on Tollers. To obtain the DNA
sample is simple and easy by swabbing the inside of your dog's cheek.
http://www.nsdtrc-usa.org/HealthResearch.htm
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Scientists Hope
to Study Addison’s Disease in Great Danes
Purina Pro Club publication 1/04:
Announcement by UCDavis that their Addison's study would be expanded to include Great
Danes (Catherine's diagnosis story was mentioned in this article!) Used with
permission from the Purina Pro Club Update newsletters, Nestle Purina PetCare.
http://www.gdca.org/health/Great%20Dane%20104.pdf
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