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NEW for JANUARY 2008
Call for BLOOD Samples for Addison’s:
Although we continue to collect DNA from buccal swab samples, newer research technologies require DNA extracted from blood samples. Thus, we are seeking blood samples from affected and unaffected dogs. Affected dogs with veterinary diagnosis can be submitted from dogs of any age. For unaffected dogs, we especially need samples from dogs over the age of 7 years that are free from the disease. Please consider donating adrenal tissue from Addisonian dogs if euthanasia becomes necessary.
There is no fee for participating in this study although the owner bears the cost of blood collection and shipping of the sample to the laboratory. Some veterinarians may collect and ship samples at no charge for research purposes – please check with your veterinarian.
In the event that your dog’s DNA from the blood sample is used directly in the development of a commercially available diagnostic test developed by this laboratory, the results of the test for that dog will be provided at no cost upon your written request following the availability of that commercial test.
The Addison's work is a collaborative study between UC Davis, Åke Hedhammar in Sweden and Kerstin Lindblad-Toh of the Broad Institute. We appreciate your continued interest in our study.
Download blood sample submission instructions here:
To request a buccal (cheek) swab kit:
To Update Your Dog's Health Status:
If you have previously submitted a dog to our study, we would appreciate regular health updates, including if the dog is still healthy.
New submissions, please click submission form at left:
If your dog is unaffected with the disease, please submit a health update annually, even if the dog is still healthy.
This kit is for participation in a research study only - it is NOT a test to verify if your dog does or does not have the disease. All submissions are confidential and results for individual dogs will NOT be made available.
CGAP Canine Genetic Analysis Project FAQs:
CGAP. Copyright © 2008 UC DAVIS. All rights reserved.
GDCA (Great Dane Club of
UPDATE on the Canine Addison's Disease
project at UC Davis under the guidance of Anita Oberbauer
(CHF Grant #225). This study has submitted it's
first progress report. The summary of the research to date is as follows.
Specific objectives are aggressively being pursued and the accumulation of
data in several breeds, including our own, continues, and is progressing
satisfactorily. To date DNA data on nearly 200 Danes has been collected. All
Danes are eligible to join the study, with an emphasis on obtaining family data
on individuals with Addison's disease. Research has already indicated than an
autosomal recessive mode of inheritance is most likely for Addison's disease,
as well as confirmed its genetic basis. Although ideally a test for the gene,
and so for carriers of the gene, would be developed, even now the study's
results offer breeders some control over the disease, and there has been some
help as well on the clinical side as to more effective diagnosis and
treatment. All this translates into an improved state of affairs as to health
and welfare for our Danes. This study has recently begun to explore some
techniques that may also help isolate the specific gene(s) involved in the
expression of canine Addison's disease. Publication is also pending. The
start date for this grant is 10--01-04 with a two year initial grant awarded.
Application for enrollment in the program is directly available from the
parent website or from UC Davis as well. It's important to remind Great Dane
owners that updates on the health status of dogs enrolled are requested and
significant to the accuracy of the data obtained. The GDCA is seeking Great
Danes to participate in this study. ALL GREAT DANES ARE WELCOME!!! Families
where at least one member has been diagnosed by a veterinarian with Addison's
disease for a potential research project into the genetics and heritability
of the disease in this breed are especially prized, but samples from anyone
wishing to participate are wanted!
Progress on the Genetics of Canine Epilepsy and Addison's Disease
Association of canine
hypothyroidism with a common major histocompatibility complex DLA class II
Nova Scotia Duck Tolling
Retriever Addison's Studies
NSDTR-USA: To request kits for the UC Davis Addison's Study on Tollers. To obtain the DNA sample is simple and easy by swabbing the inside of your dog's cheek. http://www.nsdtrc-usa.org/HealthResearch.htm
to Study Addison’s Disease in Great Danes