papers, publications, presentations, research studies
Analysis Project (CGAP) Addison's Project
"Addison’s Project Breeds under study
for this project:
Great Dane, Leonberger, Portuguese Water Dog, West Highland White
Submission Instructions & Questionnaire
Buccal Swab Kit
Health Status Update Forms
What is Addison’s Disease (Hypoadrenocorticism)?
A deficient secretion of both glucocorticoids and mineralcorticoids
from the adrenal cortex. The cause is unknown, but in most cases, there
appears to be an immune mediated destruction of the adrenal gland.
Symptoms include inappetance, vomiting, lethargy and weakness. An ACTH
stimulation test can be used for diagnosis. The test is an evaluation
of the ability of the adrenal gland to secrete cortisol. Affected dogs
show low cortisol concentrations, and no increase in cortisol following
the ACTH test. Treatment includes fluid therapy, replacement of
glucocorticoids and mineralcorticoids, and hormone therapy. The FAQs
link will answer many of your questions regarding the study. We
appreciate your support and interest in the study."
Follow the links for more information.
(Great Dane Club of America)
Scientists Hope to Study Addison’s Disease in Great Danes
Article PDF file on this site.
Progress on the Genetics of Canine Epilepsy and Addison's Disease
Presentation by Dr. Anita Oberbauer at the "Tufts Canine and Feline
Breeding and Genetics Conference" (September 30-October 1, 2005),
summarizing the current findings at UCDavis on Epilepsy and Addison's
Disease: "...We believe this approach will yield chromosomal regions
significantly linked to the Addisonian phenotype. The linkage, followed
by gene identification and genetic sequencing to identify the precise
mutation will enable the development of a diagnostic DNA based test for
breeders to integrate into their breeding program. We are hopeful that
the diversity of breeds under study will result in a test that is of
utility to all breeds."
of canine hypothyroidism with a common major histocompatibility complex
DLA class II allele
Dogs exhibit a range of immune-mediated conditions including a
lymphocytic thyroiditis which has many similarities to Hashimoto's
thyroiditis in man. We have recently reported an association in
Doberman Pinschers between canine hypothyroidism and a rare DLA class
II haplotype that contains the DLA-DQA1*00101 allele. We now report a
further series of 173 hypothyroid dogs in a range of breeds where a
significant association with DLA-DQA1*00101 is shown.
Nova Scotia Duck
Tolling Retriever Addison's Studies
Separate UCDavis study - the inheritability of Addison's Disease in
NSDTR's. Angela M. Hughes DVM, Veterinary Genetics Resident, Veterinary
Medical Teaching Hospital.School of Veterinary Medicine, University of
California, Davis, is undertaking a study on Addison's disease in the
Toller. This is Dr. Hughes' resident research project and she will be
conducting it under the guidance of Drs. Bannasch (Genetics), Oberbauer
(Genetics), Famula (Statistics), and Nelson (Internal Medicine).
NSDTR-USA: To request kits for the UC Davis Addison's Study on Tollers.
To obtain the DNA sample is simple and easy by swabbing the inside of
your dog's cheek.
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