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Analysis Project (CGAP) Addison's Project
"Addison’s Project Breeds under study for this project:
Great Dane, Leonberger, Portuguese Water Dog, West Highland White Terrier
Blood Submission Instructions & Questionnaire
Request for Buccal Swab Kit
Canine Health Status Update Forms
What is Addison’s Disease (Hypoadrenocorticism)?
A deficient secretion of both glucocorticoids and mineralcorticoids
from the adrenal cortex. The cause is unknown, but in most cases, there
appears to be an immune mediated destruction of the adrenal gland.
Symptoms include inappetance, vomiting, lethargy and weakness. An ACTH
stimulation test can be used for diagnosis. The test is an evaluation
of the ability of the adrenal gland to secrete cortisol. Affected dogs
show low cortisol concentrations, and no increase in cortisol following
the ACTH test. Treatment includes fluid therapy, replacement of
glucocorticoids and mineralcorticoids, and hormone therapy. The FAQs
link will answer many of your questions regarding the study. We
appreciate your support and interest in the study."
Follow the links for more information.
GDCA (Great Dane Club of
Scientists Hope to Study Addison’s Disease in Great Danes
GDCA Article PDF file on this site.
Progress on the Genetics of Canine Epilepsy and Addison's Disease
Presentation by Dr. Anita Oberbauer at the "Tufts Canine and Feline Breeding
and Genetics Conference" (September 30-October 1, 2005), summarizing the
current findings at UCDavis on Epilepsy and
Addison's Disease: "...We believe this approach will yield chromosomal
regions significantly linked to the Addisonian
phenotype. The linkage, followed by gene identification and genetic
sequencing to identify the precise mutation will enable the development of a
diagnostic DNA based test for breeders to integrate into their breeding
program. We are hopeful that the diversity of breeds under study will result
in a test that is of utility to all breeds."
Association of canine
hypothyroidism with a common major histocompatibility complex DLA class II
Dogs exhibit a range of immune-mediated conditions including a
lymphocytic thyroiditis which has many similarities to Hashimoto's
thyroiditis in man. We have recently reported an association in
Doberman Pinschers between canine hypothyroidism and a rare DLA class
II haplotype that contains the DLA-DQA1*00101 allele. We now report a
further series of 173 hypothyroid dogs in a range of breeds where a
significant association with DLA-DQA1*00101 is shown.
Nova Scotia Duck Tolling
Retriever Addison's Studies
study - the inheritability of Addison's Disease in NSDTR's.
Angela M. Hughes DVM, Veterinary Genetics Resident, Veterinary Medical
Teaching Hospital.School of Veterinary Medicine, University of California,
undertaking a study on Addison's disease in the Toller. This is Dr. Hughes'
resident research project and she will be conducting it under the guidance of
Drs. Bannasch (Genetics), Oberbauer
(Genetics), Famula (Statistics), and Nelson
NSDTR-USA: To request kits for the UC
Davis Addison's Study on Tollers.
To obtain the DNA sample is simple and easy by swabbing the inside of
your dog's cheek.
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