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ACTH (Adrenocorticotropic Hormone) -
the definitive diagnostic test for Addison's Diesease.
Adrenal Gland (an overview) -
The adrenal glands consist of a center core (the medulla), surrounded
by three layers of the cortex. The outer layer of the adrenal cortex
produces aldosterone (mineralocorticoids), the middle layer produces
(cortisolglucocorticoids) and the bottom/third
layer -closest to the medulla- produces sex hormones. The medulla isn't
affected by Addison's, but it's good to point out that that's where
epinephrine is produced for the "fight or flight" reaction!
Mineralocorticoid hormone produced by the adrenal glands for the
maintenance of electrolyte levels (sodium, potassium and chloride) in
Atypical Addison's -
Deficient in cortisol only. The zones of
the adrenal glands that manufacture cortisol
are no longer functioning.
Compounded Florinef -
For efficient and cost-effective treatment of Primary Canine
Addison's Disease, a "compounding pharmacist" can prepare an entire
day's dose of generic fludrocortisone
acetate in one (or two) capsules. For a compounding pharmacist near you.
Corticosteroid hormone produced by the adrenal glands for metabolism of
fat, protein and carbohydrates, production of red blood cells, stress
response, maintaining blood pressure, reducing inflammation, etc.
Cushing's Disease -
"Opposite" of Addison's -the adrenal glands OVERproduce
cortisol in a dog with Cushing's Disease.
Note: a dog with Addison's Disease that's given too much prednisone
will present the same symptoms as a dog with Cushing's Disease.
Specifically, the mineral elements in the blood: sodium (Na), potassium
(K) and chloride (Cl)
Fludrocortisone acetate, supplied in
0.1 mg tablets –this is a human medication that is prescribed
"off-label" for the treatment of Primary Canine Addison’s
Disease at a starting dosage of 0.1 mg per 10 pounds of body weight. Florinef is a mineralocorticoid
replacement that also contains a small glucocorticoid
Commonly used daily (cortisol replacement)
medication options for dogs with Atypical or Primary Addison’s Disease include: prednisone, prednisolone, “Medrol,”
Caused by medication (ex: overmedicating a dog for Cushings
Disease can cause the adrenals to shut down and the dog will become an "iatragenic Addisonian")
Of unknown cause
Aldosterone (for management/balance
of electrolytes: sodium, potassium and chloride). Medication options
for mineralocorticoid replacement in dogs
with Primary Canine Addison's Disease include Percorten-v
(DOCP), an injectable
medication that’s administered every 21-30
days -or- Florinef, a daily oral
Non-Steroidal Anti-Inflammatory Drugs, the same class as such common
over-the-counter remedies as Advil (Ibuprofen), Aleve (Naproxen), Orudis (ketoprofen),
and Aspirin. The chief use for such drugs in the dog has been pain
relief, usually joint pain or post-surgical pain relief. NSAIDS should
not be used in dogs being treated for Addison's Disease!
PD (polydipsia): excessive or abnormal
thirst; PU (polyuria): excessive urination'
Zycortal is the only medication licensed in Europe for the treatment of Addison's Disease in dogs.
Evaluation of a low-dose desoxycorticosterone pivalate
treatment protocol for long-term management of dogs
with primary hypoadrenocorticism. Journal of Internal Veterinary Medicine.
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